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Parasite Specific Antibody Increase Induced by an Episode of Acute P. falciparum Uncomplicated Malaria
(2015)
Introduction
There is no approved vaccine for malaria, and precisely how human antibody responses to
malaria parasite components and potential vaccine molecules are developed and maintained
remains poorly defined. In ...
Malariometric indices from Iganga, Uganda: baseline characterization in preparation of GMZ2 vaccine trial
(2014)
Background: Malaria still remains the leading cause of childhood morbidity and mortality in Uganda. Interventions
like malaria vaccines which reduce the malaria burden are needed in malaria endemic communities. There is ...
Development of Plasmodium falciparum specific naïve, atypical, memory and plasma B cells during infancy and in adults in an endemic area
(Bio Med Central, 2017)
Background: B-cells are essential in immunity against malaria, but which sub-sets of B-cells specifically recognize
Plasmodium falciparum and when they appear is still largely unknown.
Results: Using the flow cytometry ...
Frequency of RANTES gene polymorphisms and their association with incidence of malaria: a longitudinal study on children in Iganga district, Uganda
(Bio Med Central, 2015)
Background: The severity and outcome of malaria is influenced by host immunity in which chemokines such as
Regulated upon Activation, Normal T cell Expressed and Secreted (RANTES) play an important role. Previous studies
show ...
Novel flow cytometry technique for detection of Plasmodium falciparum specific B‑cells in humans: increased levels of specific B‑cells in ongoing infection
(Malaria Journal, 2015)
Background: Malaria caused by Plasmodium falciparum is still a major health threat in endemic areas especially for
children below 5 years of age. While it is recognized that antibody immunity plays an important role in ...
Prevalence of glucose-6-phosphate dehydrogenase deficiency and its association with Plasmodium falciparum infection among children in Iganga distric in Uganda
(Biomed central, 2014)
Background: Glucose-6-phosphate dehydrogenase (G6PD) is a metabolic enzyme involved in the pentose phosphate
pathway, its especially important in red blood cell metabolism. Glucose-6-phosphate dehydrogenase deficiency is ...
Polymorphisms in Plasmodium falciparum Chloroquine Resistance Transporter and Multidrug Resistance 1 Genes: Parasite Risk Factors that Affect Treatment Outcomes for P. falciparum Malaria after Artemether-Lumefantrine and Artesunate-Amodiaquine
(2014)
Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component
and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter ( pfcrt) ...
Differences in affinity of monoclonal and naturally acquired polyclonal antibodies against Plasmodium falciparum merozoite antigens
(2015)
Background: Malaria is a major global cause of deaths and a vaccine is urgently needed.
Results: We have employed the P. falciparum merozoite antigens MSP2-3D7/FC27 and AMA1, used them in ELISA,
and coupled them in ...
Prevalence and factors associated with low back pain among healthcare workers in kibuli Muslim hospital kampala, Uganda
(OIMICS International, 2017)
Background: Low back pain was not only considered to be the most common reason for functional disability
worldwide, but also estimated to have affected 90% of the universal population. This study aimed at determining ...
Individual risk factors contributing to the prevalence of teenage pregnancy among teenagers at Naguru teenage center kampala, Uganda
(Primary Healthcare: Open Access, 2016)
Introduction: Teenage pregnancy and its effects on teen motherhood are among the major societal challenges
of the teenagers in the contemporary global community. In a 30 million population 25 percent pregnancy rate ...